The effect of ketogenic diet on type II diabetes

taher, Shahed (2020-03-12)

Diabetes mellitus (DM) could be a serious universal ill health. The prevalence of this condition is rapidly increasing in the world , Changes in lifestyle and dietary habits, in conjunction with genetic susceptibility, have resulted in a very remarkable increase within the incidence and prevalence of diabetes within the world. Type 1 diabetes, or insulin-dependent diabetes (IDDM), is caused by the autoimmune destruction of pancreatic b cells leading to insulin deficiency. Hence, the administration of insulin is important for the metabolism and survival of those patients. Type 1 diabetes accounts for less than 5–10% of all the diabetic cases , Type 2 diabetes, on the opposite hand, is due to impaired insulin secretion and/or insulin resistance , This type of insulinindependent diabetes is far more widespread and accounts for nearly 90–95% of the DM cases.In a diabetic patient , the ingested carbohydrates are absorbed mainly as glucose, there's an instantaneous rise within the blood glucose level. The contents of anketogenic diet with low-carbohydrate ( LCKD ) are mainly absorbed as triglycerides and proteins instead of glucose, so this might alleviate one among the key factors in diabetes . (2( This this study is geared toward investigating the therapeutic effects of LCKD in diabetic rats .


Changes in dietary habits influence the glycemic level.using the low-carbohydrate ketogenic diet (LCKD) were found to be quite promising in controlling diabetes mellitus. Therefore, by analyzing the therapeutic effects of LCKD in experimental diabetic rats following the administration of streptozotocin (STZ) , Adult rats were divided into three groups: normal diet, LCKD, and high-carbohydrate diet. Each group was subdivided into normal, sham, and diabetic groups.The results showed that LCKD was effective in bringing glucose level to normal (P<0.01).This study indicates that LCKD contains a significant beneficial effect in ameliorating the diabetic state and helping to stabilize hyperglycemia .

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