dc.description | Oral candidiasis is recurrent infections of the oral cavity caused by an uncontrold growth
of Candida species, fungi are free-living, eukaryotic organisms that exist as yeasts (round
fungi), moulds (filamentous fungi), or both (dimorphic fungi). Candida normally lives on
the skin and inside the body, in places like the mouth, throat, gut, and vagina, without
causing any problems. Oral candidiasis is a significant source of morbidity, as it can
cause chronic pain or discomfort upon mastication, limiting nutrition intake in the elderly
or immunodeficient patients.
Regional or systemic factors may be predisposing factors for oral candidiasis. For
example, the local causes, salivary gland dysfunction, and saliva constituents such as
histidine-rich polypeptides, lactoferrin, and lysozyme may be predisposed to oral
candidiasis. (Scully et al., 1994; Ship & Turner, 2007).
Dental prostheses create a favorable micro-environment for the growth of candida
species. Around 65 per cent of full denture wearers are predisposed to candida infection.
(Martori et al., 2005; Ashman and Farah, 2014).
The use of topical or inhalational corticosteroids and overzealous use of antimicrobial
mouthwashes may be another significant local factor that raises the risk of oral
candidosis. We temporarily remove local immunity and induce changes in the oral flora
(Scully et al., 1994; Jainkittivong et al., 2007).
Some research indicate that smoking alone or in conjunction with other factors
significantly affects the carriage of oral candida while the possible reasons for promoting
colonization of candida include localized epithelial changes caused by smoking
(Arendorf and Walker, 1980). Unbalanced dietary intake of refined sugars,
carbohydrates, and dairy products (with a high lactose content) may be likely serve as
Development enhances by reducing pH levels and thereby encouraging the production of
candida species (Martins et al., 2014). | en_US |
dc.description.abstract | Background: Oral Candidiasis is one of the recurrent fungal infection affecting the oral
mucosa. It is a commensal organism of normal oral flora which is capable of opportunistic
infections. Candida albicans are recovered from 60% of dentate patients mouth over the
age of 60 years. There are three general factors which allows the Candida
albicans contamination to develop inside the patient’s body includes Immune status of
the patient, oral mucosal environment, and strain of Candida albicans
. Early sign of host protection breakdown is neutropenia whereas risk factors include:
antibiotics, immunosuppression, diabetes, HIV, steroids, nutritional deficiency,
Radiation/Chemotherapy | en_US |