Histopathological study of prostate cancer in Libyan patients in Eastern region between years (2015 to 2018)
1.1 Anatomical structures of the prostate The human prostate at the base of the urinary bladder is a walnut-sized organ. The prostatic urethra is enveloped by a fibromuscular glandular organ The inverted coin, as it is located just below the urinary bladder, measures approximately 3cm in diameter and is located superiorly between the bladder neck and the urogenital diaphragm. 1.1.1 Relations Apex is associated with the bladder's neck . The base is linked to the urogenital diaphragm . Ventrally connected to the pubis symphony but separated by extraperitoneal fat and its dorsally associated rectum and separated from it by fascia denonvilliers Laterally, the prostate is connected to the dorsal aspect. 1.1.2 Structure of the prostate Plentiful glands of the prostate are planted into a mixture of smooth muscle and connective tissue the ducts opens towards the prostatic urethra. The prostate is inadequately branched into five lobes . The ventral one lies towards the urethra and its bare from glandular tissue, the middle lobe is the chunk of the gland locates between the urethra and ejaculatory duct, its superior surface is linked to bladder trigon, dorsal lobe is located behind the urethra. Right and left lateral lobes are located on each side of urethra and they are detached from one another by a flat vertical groove. 1.3 What is a tumor It is an abnormal cell aggregation that will eventually lead to swelling, but not all swellings are cancerous. If the tumor is either benign or malignant, it all depends on the cell growth pattern, so logical if it has normal cell growth is called benign and if there is an abnormal development pattern, it is called malignant.
Prostate cancer is more common in men over the age of 65 years and the second leading cause of death among men in the United States. We studied prostate cancer (n=239) with regards to age, histopathological types, grade, and stages between years (2015 to 2018) using H&E stained section. All cases were histologically adenocarcinoma with different grades. Most of the cases were ≥65 (90%), grade 1 (35.6%), stage IV (89.8%) and most of them presented with back pain (47.1%). Majority of cases show gradual decrease in PSA level after the patient underwent surgery, hormonal and chemotherapy (36.4%).