Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is autoimmune disease in which the body's immune system mistakenly attacks healthy tissue in many part of the body. The SLE is chronic inflammatory disease that has protean manifestations and follows a relapsing and remitting course. More than 90% of cases of SLE occur in women, frequently starting at childbearing age. Common symptoms include painful and swollen lymph nodes, feeling tired, and a red rash which is commonly in the face. SLE can occur in up to 20% of patients 50 years of age or older. SLE affects almost every system in the body, with varying degrees of severity. Recent advances in our understanding of the genetic, molecular and cellular basis of autoimmune diseases and especially SLE have led to the application of novel and targeted treatments. This article reviews the general approach to the therapy of SLE, focusing on current approved therapies