Effects of Metformin on Early Pregnancy Loss in the Polycystic Ovary Syndrome

El-Gheriani, Fatma Abdelsalam (2018-05-03)

women with polycystic ovary syndrome are at increased risk of miscarriage after either spontaneous or assisted conception. Rates of early pregnancy loss, defined as miscarriage during the first trimester, are reported to be 30–50% in women with polycystic ovaries or the polycystic ovary syndrome , which is 3-fold higher than the rate of 10–15% reported in retrospective studies for normal women . Keeping in mind that these were retrospective case studies of clinically recognized pregnancies, the true miscarriage rates for both women with polycystic ovary syndrome and normal women were likely underestimated. Conversely, 36–82% of women with recurrent early pregnancy loss are reported to have polycystic ovary syndrome .Previous studies have suggested that women who hypersecrete LH, a frequent feature of the polycystic ovary syndrome, are at increased risk for miscarriage after either spontaneous or assisted conception , it was recently reported that suppression of endogenous LH release before conception, in women with elevated circulating LH concentrations and a history of recurrent miscarriage, did not improve the live birth rate


POLYCYSTIC OVARY SYNDROME is the most common form of female infertility in the United States, and it affects 5–10% of women of reproductive age . Metformin has been introduced as a therapeutic option in PCOS , and in this report will be discus the effect of metformin in ealy pregnancy loss in the Polycystic Ovary Syndrome .

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