Infective endocarditis (IE) is an infection of the heart valves. A large number of different microorganisms are capable of causing this disease. Depending on the particular pathogen, endocarditis can be indolent, progressing slowly over weeks to months, or fulminant, presenting with a very toxic picture over several days. In the preantibiotic era, this disease was almost uniformly fatal. While endocarditis can now be treated medically, it is a classic example of an infectious disease where "bactericidal" antibiotics are absolutely necessary because the local and systemic host defense mechanisms are of limited benefit.
In this report we are going to discuss mechanism of infective endocarditis , the major and minor criteria (diagnose) and the way of treatment.