Therapeutic Effects of Ketone Diet in Epilepsy
Epilepsy is a common brain disorder characterized by recurrent seizures. Approximately 50 million people worldwide have epilepsy, making it one of the most common neurological diseases globally1 . A wide range of antiepileptic drugs has been developed, however about 30% of patients with epilepsy fail to respond. A high-fat, lowcarbohydrate diet known as a ketogenic diet was developed to assist such patients, its beneficial effects has been confirmed by a variety of clinical trials, one of them have showed 75% decrease in seizures in children on a ketogenic diet for three months. Even with these amazig results the excact mechanism through which a ketogenic diet excert its anticonvulsant effects is unclear
Ketogenic diet (KD) is a very low-carb diet, which forces the body to burn fat instead of carbs making the body produce ketones as a fuel, this is an alternative fuel used in conditions where glucose levels are low or for the treartment of seizures. KD has been proven to be effective as a medical therapy for epilepsy allowing patients to take less or no anti-epileptic drugs (AEDs), also providing a new line of therapy for those unresponsive to AEDs. Despite its successful results, the exact mechanisms by which KD works remains unclear. This is a collective review on the potential machanisms by which KD exert its anti-seizures properties.