Genetic basis of Ehlers-Danlos syndrome

In this report, we will discuss the genetic and biochemical data, the current Villefranche classification subdivides EDS into six major subtypes, , which are caused by mutations in genes encoding fibrillar collagens or enzymes involved in collagen biosynthesis. Mutations in type V and type III collagen cause classic and vascular EDS, respectively, whereas mutations affecting the processing of type I collagen lead to the kyphoscoliotic, arthrochalasic and dermatosparactic EDS types