Effect of Coffee in Improvement of Alzheimer's disease

Alshikhi, Sara Almabrouk Hamad (2018-04-14)

Caffeine, the principal alkaloid in coffee, tea, and energy drinks, is one of the most consumed psychoactive substances in the world  Studies suggest that coffee consumption affects health-related variables such as cancer ,exercise performance, diabetes, and blood pressure. Caffeine has been shown to affect multiple aspects of the central nervous system

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The therapeutic benefits of coffee consumption against AD are apparent from various recent research studies  Research indicates that caffeine in the diet is linked to the reduction of hyperphosphorylated tau and can reduce the severity of AD symptoms  Caffeine is a non selective adenosine A2Areceptor antagonist  The A2A receptor is also expressed in the brain, where it has important roles in the regulation of glutamate and dopamine release, making it a potential therapeutic target for the treatment of conditions such as insomnia, pain, depression, and Parkinson's disease

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Attribution 3.0 United States
Except where otherwise noted, this item's license is described as Attribution 3.0 United States