Autoimmune Fetal Congenital Heart Block
Elrgeig, Hajer Khalil (2019-04-26)
Autoimmune fetal Congenital heart block (CHB) is a severe, life-threatening disorder and the most severe manifestation of neonatal lupus, that associated with passive transfer of maternal anti-Ro/SSA and anti-La/SSB auto-antibodies that cross the placenta and bind to cardiomyocytes, and the atrioventricular (AV) conduction system is disrupted by inflammation with subsequent fibrosis and calcification leading to a complete AV block.(1,2) It is typically develops between 20 and 24 weeks of gestation
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