Systemic Lupus Erythematosus
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Date
2018-05-05
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faculty of Basic Medical Science - Libyan International Medical University
Abstract
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Systemic lupus erythematosus (SLE) is autoimmune disease in which the body's immune
system mistakenly attacks healthy tissue in many part of the body. The SLE is chronic
inflammatory disease that has protean manifestations and follows a relapsing and remitting
course. More than 90% of cases of SLE occur in women, frequently starting at childbearing
age. Common symptoms include painful and swollen lymph nodes, feeling tired, and a red
rash which is commonly in the face. SLE can occur in up to 20% of patients 50 years of age
or older. SLE affects almost every system in the body, with varying degrees of severity.
Recent advances in our understanding of the genetic, molecular and cellular basis of
autoimmune diseases and especially SLE have led to the application of novel and targeted
treatments. This article reviews the general approach to the therapy of SLE, focusing on
current approved therapies
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