Paget’s Disease & Risk Of Spinal Stenosis
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Date
2019
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faculty of Basic Medical Science - Libyan International Medical University
Abstract
Introduction: Paget's bone disease interferes with the usual recycling process in your
body, in which new bone tissue is gradually replacing old bone tissue. Over time, the
disease can cause the bones affected to become fragile and disfigured. Most
commonly Paget's bone disease occurs in the pelvis, skull, spine, and neck.
Materials and Methods: Of the 754 cases, 101 cases were of monostotic or
polyostotic spine involvement. There were 29 cases of PDB in the spinal cord (16
males; 13 females) available for histological and histomorphometric analysis.
Results: The most common PDB manifestation site was the lumbar spine (62.2 %),
followed by the thoracic spine (29.6 %). The cervical spine was involved in 8.2 % of
patients.
Conclusion: In brief, the lumbar stenosis is the most common site in spinal stenosis
Description
Typical vertebrae are a vertebral body, a vertebral spine, and seven processes. As the
column goes down, the vertebral bodies increase in size. The vertebral body consists
of a trabecular bone containing the red marrow, surrounded by a thin layer of compact
bone from the outside. The arch, together with the back side of the body, forms the
vertebral (spinal) canal containing the spinal cord.
Paget's disease of bone (PDB) is the second most common type of bone disease after
osteoporosis. It is a disorder of the bone remodeling process due to an increase in
osteoblastic and osteoclastic activity, that lead to resorb old bone and forms deformed,
enlarged, and fragile new bones. There are factors that can increase your risk to get
Paget’s disease like Age (>40), sex and family history, and one of the complications
of Paget’s disease is spinal stenosis.
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