Relation between Folic Acid and Neural Tube Defect
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Date
2020-02-24
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faculty of Basic Medical Science - Libyan International Medical University
Abstract
Neural tube defects (NTDs) are common complex congenital malformations resulting
from failure of the neural tube closure during embryogenesis, a lot of studies established
that folic acid supplementation decreases the prevalence of NTDs, this report
summarizes some of these studies, which have led to the current situation in which all
women capable of becoming pregnant should consume 400 micrograms of folic
acid/day for the purpose of reducing this risk. The folate-NTD relation represents the
only instance in which a congenital malformation can be prevented simply and
consistently. Nevertheless, several research gaps remain: identification of the
mechanism by which the defect occurs and how folate ameliorates it, characterization
of the relative efficacy of food folate, folic acid added to foods, and folic acid by itself;
delineation of the dose-response relations of folate and NTD prevention
Description
Insufficiency of folate during early pregnancy is associated with increased risk of birth
defects. Women of a particularly poor population subgroup manifested severe anemia
during pregnancy, early abortions, and malformed births. The vitamin folate has been
discovered and purified in 1945, during the first 2 decades after folate discovery, large
doses of folic acid have been used to correcting anaemia and/or neurological
manifestations. (
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