Clinical trials of Ebola virus treatment
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Date
2020-03-12
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faculty of Basic Medical Science - Libyan International Medical University
Abstract
Ebola virus disease (EVD) is a deadly incurable illness; however there are ways and
stratgies by which the treatment could be reashed . some of which are, by inhibiting
the action of viruse glycoproteins therby preventing viral entery into the host cell, by
interrupt transcraption of the viruse and that happeing by preventing the
dephosphoraltion of VP30 viral factor that is needed in transcription of the virus and
it must be in its dephosphoraltion form, by iteraction between ebola viurs protein
(VP30) and human protein (RBBP6) which has an ability to stop Ebola viruse life
cycle.
Description
Ebola virus disease (EVD), one of the deadliest viral diseases, was discovered in 1976
when two consecutive outbreaks of fatal hemorrhagic fever occurred in different parts
of central Africa. The first outbreak occurred in the Congo in a village near the Ebola
river, which gave the virus its name, the second outbreak occurs what is now south
Sudan. The largest outbreak to date took place in West Africa between march 2014
and June 2016; it resulted in 28,646 cases and 11,323 deaths and affected 10 countries
in Africa, Europe, and North America.
(1)
Ebola virus (EBOV), member of the Filoviruses which are family of viruses that are
appearing as long filamentous threads or as odd-shaped. Moreover, Filoviruses are
highly virulent and require maximum containment facilities ( Biosafety level 4 ).
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