Nanoparticle Approaches Against Bacterial Infections
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Date
2018-04-13
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faculty of Basic Medical Science - Libyan International Medical University
Abstract
A number of nanoparticle-based drug delivery systems have been approved for clinical use to
treat a variety of infectious diseases, and many other antimicrobial nanoparticle formulations
are currently under various stages of pre-clinical and clinical tests.Three studies were included
in this report to support the effectiveness of nanoparticle-based drug delivery. The first study
demonstrated the approach to selectively deliver antimicrobials to the sites of bacterial
infections by utilizing bacterial toxins to activate drug release from gold nanoparticle-stabilized
phospholipid liposomes. While the second and third study showed the effectiveness of PHsensitive
drug release from liposomes in different sites.
Description
Over the last few decades, the application of nanotechnology, particularly the use of
nanoparticles for drug delivery, has generated significant impact in medicine. Various
nanoparticle delivery platforms, especially liposomes, polymeric nanoparticles, dendrimers,
and inorganic nanoparticles, have received significant attention. Drug molecules loaded into
nano-carriers through physical encapsulation, adsorption, or chemical conjugation exhibit an
improved pharmacokinetic profile and therapeutic index when compared to their free drug
counterparts. Other advantages of nanoparticle delivery systems, including improved drug
solubility, prolonged systemic circulation, sustained and controlled release, precise drug
targeting, and concurrent delivery of multiple drugs, have also been validated in various
studies
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Except where otherwised noted, this item's license is described as Attribution 3.0 United States
