Vitamin D deficiency and heart failure
Loading...
Date
2020-03-01
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
faculty of Basic Medical Science - Libyan International Medical University
Abstract
Vitamin D is principally known for its role in calcium homeostasis, but preclinical studies
implicate multiple pathways through which vitamin D may affect cardiovascular function
and influence risk for heart failure. Cross sectional studies demonstrated that prevalence
of HF is increased in patients with Vitamin D deficiency or parathyroid hormone (PTH)
plasma level increase, whereas longitudinal studies showed enhanced risk of developing
new HF in patients with Vitamin D deficiency. In addition, in patients with established
HF, low plasma levels of Vitamin D are associated with worsening clinical outcome. Yet,
clinical studies did not definitively demonstrate a benefit of Vitamin D supplementation
for preventing HF or ameliorating clinical outcome in patients with established HF.
Aim: The aim of this review was to summarize evidence on the role of Vitamin D
deficiency in heart failure (HF), from pathophysiological mechanisms side
Description
With the improvement of care in the prevention of high blood pressure (hypertension),
smoking, and dyslipidaemia, coupled with technological advances in the diagnosis and
treatment of cardiovascular diseases (CVDs), there was a decline in the mortality rate due
to CVD in the elderly; however, CVD is the leading cause of morbidity and mortality in
the world and the most chronic disability .
1 Vitamin D is a steroid hormone belonging to
the group of lipid-soluble vitamins.3
It is estimated that nearly 30–50% of the world
population suffers vitamin D deficiency
Keywords
Citation
Collections
Endorsement
Review
Supplemented By
Referenced By
Creative Commons license
Except where otherwised noted, this item's license is described as Attribution 3.0 United States