Prevalence of cardiovascular malformations in Turner's syndrome
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Date
2019-03-11
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faculty of Basic Medical Science - Libyan International Medical University
Abstract
The purpose of their study was to establish the prevalence of cardiovascular
malformations and investigate any possible associations between the various
genotypes and cardiovascular malformations. One hundred and seventy nine of 393
females who had Turner's syndrome diagnosed in Denmark were examined .
Complete chromosome analysis was available in all cases .
Description
Turner's syndrome is a genetic abnormality in females and the karyotype can be
monosomy X (45,X), mosaic monosomy X, or a structural abnormality of the X
chronosome. The syndrome is characterised by shdrt stature and gonadal dysgenesis,
and is associated with a number of congenital abnormalities including cardiovascular
malformations. In published series of Turner's syndrome the percentage of those with
cardiovascular malformations has ranged from 17% to 47%; aortic coarctation and
bicuspid aortic valve being the most common lesions.
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