Role of BRCA1 in Diagnosis of Triple Negative Breast Cancer
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Date
2020-03-12
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faculty of Basic Medical Science - Libyan International Medical University
Abstract
Triple-negative (TN) tumors are considered to be the most common subtype breast
cancer in individual who carry BRCA1 mutation. in the recent years BRCA1 testing
was advised to be offered to all individuals who are below 50 years and whom carry
Triple negative breast cancer. Furthermore BRCA1 mutation frequency and the
amplification for clinical practice of undertaking genetic testing in women with TN
breast cancer have been evaluated.
Description
Breast cancer is a type of cancer that starts in the breast, when cells begin to grow out
of control, and Breast cancer cells usually form a tumor that can often be seen on an
x-ray or felt as a lump. Breast cancer occurs almost entirely in women, but men can
get breast cancer, too. TNBC (Triple Negative Breast Cancer) is cancer that tests
negative for three hormones receptors, estrogen receptors, progesterone receptors, and
have little or no HER2 protein expression.
(5,6)
The lacking of expression of estrogen receptor (ER), progesterone receptor (PR) and
human epidermal growth factor receptor (HER2) describe the TNBC ( Triple
Negative Breast Cancer ) which is a subgroup of tumors(1)
, However, TNBC ( Triple
Negative Breast Cancer ) are a collection of different breast cancers that are still
poorly characterized at the molecular level, and lack definitive prognostic markers
and selective targets of therapy(2)
. Although its incidence is still high, the overall
mortality due to breast cancer has decreased, in addition, it accounts for about 15% of
all breast cancers, and it occurs more in younger women than the older ones and it
occurs more frequently in individuals with a germline BRCA1 mutation.(3)
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Except where otherwised noted, this item's license is described as Attribution 3.0 United States