Relationship between Gout and kidney disease
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Date
2020
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faculty of Basic Medical Science - Libyan International Medical University
Abstract
Through this topic will be learning a bout, Relationship between Gout and kidney disease, How
Gout increase the risk of kidney Disease, and increase the level of uric acid.
Hyperuricemia and gout, the clinical manifestation of monosodium urate crystal deposition are
common in patients with chronic kidney disease CKD.
While the presence of CKD poses additional challenges in gout management. effective urate
lowering is possible for most patients with CKD, initial doses of urate lowering therapy are
lower than in the non CKD population, while incremental dose escalation is guided by regulars
monitoring of serum urate to reach the target.
management of gout flares with presently available agents can be more challenging due to
potential nephrotoxicity and or contraindication in the setting of other common comorbidities.
Description
Uric acid is the final oxidation product of purine metabolism and is really excreted serum uric
acid levels are seen in patients with reduced glomerular filtration rate CGFRL , However in
recent years , it has been proposed that uric acid itself plays a role in the pathophysiology of
chronic kidney disease and possibly in acute kidney injure –
Demostrates uric acid – related cellular changes that contributes to renal disease. Thus far, it
remains unclear whether these changes are reversible upon treatment of hyperuricemia, it also
remains unclear whether uric acid level can be a maker of impending renal decline.
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