Resistance to First and Second- Line Anti-tuberculosis Drugs
Loading...
Files
Date
2020-03-12
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
faculty of Basic Medical Science - Libyan International Medical University
Abstract
Infections with multidrug-resistant and extensively drug-resistant tuberculosis cause
public health problems around the world. Regional epidemiological data on the drug
resistance of Mycobacterium tuberculosis isolate (Mtb) is crucial to direct effective
clinical therapy to treat patients and to curb tuberculosis spread.
Antituberculosis susceptibility tests were conducted for 287 Mtbs including 63
MDRMtbs collected from 2011 to 2015 in southern Taiwan. Patients with
tuberculosis were divided into newly diagnosed cases and previously identified based
on their medical history.
Almost no resistance of non-MDR-Mtbs to tested second-line antituberculosis drugs.
Anti-tuberculosis treatment with pyrazinamide, ethambutol, fluoroquinolone,
kanamycin, cycloserin and p-aminosalicylic acid can be used empirically for new
applications
Description
Tuberculosis is a chronic granulomatous disease caused by Mycobacterium
tuberculosis usually affects the lung but it can spread other organs or tissues.
Mycobacterium tuberculosis is transmitted from person to person by respiratory
aerosols produced by coughing.
General characteristic of Mycobacterioum tuberculosis (Mtb):Shape :Slender, slightly
curved rod, 2 - 4 µm in length and 0.2 - 0.5 µm in width, Non motile and non spore
forming,Cell wall :Complex peptidoglycane arabinogalactan mycolate cell wall; 60%
lipid. Stain :Poorly stained with Gram stain; neither Gram +ve nor Gram –ve, It is
acid-fast because of the long chains of fatty acids called mycolic acids. Culture:They
are aerobes,Grow slowly (15-20 hr ),Optimum temperature for growing is
37˚C,Optimum pH for growing is 6.4 - 7.0, Grow only on Löwenstein Jensen
media,Colonies appear in 2-6 weeks
Keywords
Citation
Collections
Endorsement
Review
Supplemented By
Referenced By
Creative Commons license
Except where otherwised noted, this item's license is described as Attribution 3.0 United States