New Strategy For Stimulating Autophagy
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Date
2018-06-30
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faculty of Basic Medical Science - Libyan International Medical University
Abstract
Autophagy has become a hot topic in recent years, earning its discoverer the Nobel Prize in
Physiology and Medicine in 2016. The process involves the rounding up of misfolded
proteins and obsolete organelles within a cell into vesicles called autophagosomes. The
autophagosomes then fuse with a lysosome, an enzyme-containing organelle that breaks
down those cellular macromolecules and converts it into components the cell can re-use.
Description
Autophagy is a process in which long-lived proteins, damaged cell organelles, and other
cellular particles are sequestered and degraded. This process is important for maintaining the
cellular microenvironment when the cell is under stress.
Autophagy plays a direct or indirect role in health and disease. A simplified definition of
autophagy is that it is an exceedingly complex process which degrades modified, superfluous
(surplus) or damaged cellular macromolecules and whole organelles using hydrolytic
enzymes in the lysosomes. It consists of sequential steps of induction of autophagy,
formation of autophagosome precursor, formation of autophagosome, fusion between
autophagosome and lysosome, degradation of cargo contents, efflux transportation of
degraded products to the cytoplasm, and lysosome reformation
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Except where otherwised noted, this item's license is described as Attribution 3.0 United States