Role of hypoxia inducible factor 1α as a potential target in cancer therapy
| dc.contributor.author | Elraid, Amani Omar | |
| dc.date.accessioned | 2020-07-07T10:12:00Z | |
| dc.date.available | 2020-07-07T10:12:00Z | |
| dc.date.issued | 2020-02-27 | |
| dc.description | Hypoxia inducible factor (HIF) is a heterodimer transcription factor composed of one of three alpha (α) subunits and a beta (β) subunit. The expression of HIF-α is induced under hypoxic conditions, HIF-1α and HIF-2α are shown to be regulator in transcriptional response to hypoxia, they have similar protein structure (48% amino acid sequence similarity), but different target genes and regulatory mechanism. HIF3α is the newest member of the family and its role is still unclear. HIF-1β is constitutively expressed, which is a partner of aryl hydrocarbon receptor (AhR) it binds to AhR helping its translocation to the nucleus, so it is also referred to as aryl hydrocarbon nuclear translocator (ARNT). HIF-1α is encoded by HIF1A gene, which is located in chromosome 14, that is expressed in most tissues with highest levels in kidneys and heart | en_US |
| dc.description.abstract | Our cells response to low oxygen tension (hypoxia) by transcriptional induction of a series of genes, this induction is mediated by hypoxia-inducible factors (HIFs), which are family of transcription factors consist of one of three α subunits (HIF-1α, HIF-2α, HIF-3α) and β subunit (HIF-1β). HIF-1α expression is induced by hypoxia, it was found that it is a master regulator of angiogenesis and plays a critical role in glucose metabolic pathways which provide physiologic adaptation and cell survival during hypoxic conditions. Clinical investigations have been shown a correlation between overexpression of HIF-1 and aggressive cancer progression, which may be expected considering the fact that cancer cells are known to be hypoxic. Thus, targeting HIF-1 could represent a novel approach to cancer therapy, as it allows for survival and proliferation of cancerous cells due to its angiogenic and metabolic properties | en_US |
| dc.identifier.uri | http://repository.limu.edu.ly/handle/123456789/1732 | |
| dc.language.iso | en | en_US |
| dc.publisher | faculty of Basic Medical Science - Libyan International Medical University | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.title | Role of hypoxia inducible factor 1α as a potential target in cancer therapy | en_US |
| dc.type | Other | en_US |