The Role of Coffee in Alzheimer Disease

Doghman, Ahlam Abdulsalam Salem (2020-02-17)

Alzheimer disease (AD) is a neurodegenerative disorder; the most common cause of dementia in older adults, with an increasing incidence as a function of age [1, 2]. The disease usually manifests with memory impairment, altered mood and behavior, and loss of learned motor skills and language. Over time, disorientation and aphasia often develop; patients in the final phases of AD often become mute and immobile [1]. The fundamental abnormality in AD is the accumulation of two proteins amyloid-beta peptide (Aβ) and naturally present Tau protein in the forms of plaques and tangles, respectively; in specific brain regions, and the definitive diagnosis of AD is based on the observation of characteristic brain lesions: senile plaques and neurofibrillary tangles


Alzheimer disease (AD) is the most frequent cause of dementia in elderly. It leads to progressive cognitive decline due to accumulation of two proteins (β-amyloid peptide (Aβ) and Tau) in the forms of senile plaques and neurofibrillary tangles in the brain. A lot of studies suggest that regular moderate coffee consumption over a lifetime reduces the risk of developing AD, particularly in the elderly. Caffeine has well- known short-term stimulating effects on central nervous system, but the long-term impacts on cognition have been less clear. Thus, the putative protective effect of caffeine against AD is of great interest. In this report, we discuss the neuroprotective effect of caffeine in AD. The findings of the previous studies indicate the ability of moderate caffeine intake to protect against AD via prevention of (Aβ) buildup. This finding might open possibilities for prevention or postponing the onset of AD. In conclusion, coffee drinking may be associated with a decreased risk of AD.

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