Hematological malignancy Associated with Anemia

AHMED, SALMA (2020-03-11)

Anemia occurring in patients with MM is multifactorial Several factors have been implicated in the pathogenesis. Malignant plasma cells can supplant normal plasma cells in the bone marrow This infiltration can lead to BM failure and anemia. Multiple Myeloma is a clonal disorder of plasma cells that accounts for approximately one percent of all cancers and ten percent of hematologic malignancies. It is a disease of the elderly with a median age at diagnosis of 66 years and less than 10% of cases occurring in patients younger than 50 years. Although new therapeutics have improved the prognosis, myeloma remains incurable with a median survival of 7–8 yrs It is 2–3 times more common in African Americans than in whites and is slightly more common in men than women


Multiple myeloma (MM) accounts for 1% of all malignancies and more than 10% of hematologic neoplasms. The disease is more common in elderly people, and blacks are affected twice as frequently as whites. The cause of MM is unknown, although significant progress has been made to have a better understanding of the pathogenesis. The disease is very heterogeneous in terms of its extend complications sensitivity to drugs and clinical course, and manifestations vary widely among patients. Anemia is a common clinical manifestation in patients with MM

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