Vitamin D role in Breast Cancer Prevention
Vitamin D is a fat-soluble nutrient that's present in few nourishments, and available as a dietary supplement. it's produced in two forms, vitamin D2 and D3.Vitamin D3 form is produced from 7-dehydroxycholesterol converted to cholecalciferol in skin layers (dermis and epidermis) exposed to sunlight. It’s also found in tissue , ingredient and fortified food (milk, yogurt, cheese). In contrary, Vitamin D2 (Ergocalciferol) found in plant, mulch and yeast. Vitamin D induce calcium absorption inside the stomach and supports enough serum calcium and phosphate concentrations to enable normal mineralization of bone and to stop hypokalemic tetany. it's also needed for bone growth and bone remodeling by osteoblasts and osteoclasts. Without sufficient cholecalciferol , bones can become thin, brittle, or misshapen. vitamin D adequacy prevents rickets in children and osteomalacia in adults. beside calcium, it also helps protect older adults from osteoporosis
Breast cancer is a significant public health problem in developing countries as it is one of the most common cancers, being the most if only the female population is considered. The occurrence is diminishing every year, which is partially due to quick detection program. In the last decades, cellular in vitro experiments and in vivo models have evaluated the role of vitamin D in the development of breast cancer, finding a protective anticancer role of 1,25(OH)D3 the active form of vitamin d. The evidence submits that determinations to develop vitamin D status, for instance by vitamin D supplementation and sun light exposure, might diminish cancer occurrence and mortality at low cost, with little or no adverse effects .