Relationship between Human Immunodeficiency virus infection and cancer
Viruses are very tiny germs they are made of genetic material inside of a protein coating Numerous viruses introduce DNA damage and genetic instability in host cells during their lifecycles and some species also manipulate components of the DNA damage response Human immunodeficiency virus (HIV) infection is a viral infection that progressively destroys certain white blood cells and can cause acquired immunodeficiency syndrome (AIDS).Both HIV -1 and HIV -2 cause (AIDS HIV is one of the two important human T-cell lymphotropic retroviruses is perfentially infects and Kills helper (CD4 ) T lymphocytes, and other cell that have CD4 protein on their surface resulting in loss of cell -mediated immunity and probability that the host will develop opportunistic infection . This viral classified into lentivirus which cause Slow infection with Long incubation periods . HIV has bae shaped (type D) core surrounded by an envelope containing virus -specific glycoproteins (gp120 and gp41) .
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The acquired immune deficiency syndrome (AIDS) defined as HIV infection associated with an absolute CD4 count below 200/uL and it cause by chronic infection with the human immunodeficiency virus type 1 (HIV-1) leads to severe immunosuppression and death from immunologic and neurologic dysfunction . AIDS-defining opportunistic infection or AIDS-defined cancer, including Kaposi sarcoma (KS), non-Hodgkin lymphoma, and cervical cancer. About 40% of HIV-associated malignancies are associated with oncogenic viruses, including human papillomavirus (HPV), Epstein-Barr virus (EBV), human herpesvirus 8(HHV-8), and hepatitis B and C viruses. Human immunodeficiency virus (HIV) infection is correlated with an augmented incidence of specific types of cancer, namely Kaposi sarcoma, non-Hodgkin´s lymphoma and cervical cancer, all associated with r chronic infection by oncogenic virus.
