Relationship between Gout and kidney disease

2048, Bushra (2020)

Uric acid is the final oxidation product of purine metabolism and is really excreted serum uric acid levels are seen in patients with reduced glomerular filtration rate CGFRL , However in recent years , it has been proposed that uric acid itself plays a role in the pathophysiology of chronic kidney disease and possibly in acute kidney injure – Demostrates uric acid – related cellular changes that contributes to renal disease. Thus far, it remains unclear whether these changes are reversible upon treatment of hyperuricemia, it also remains unclear whether uric acid level can be a maker of impending renal decline.


Through this topic will be learning a bout, Relationship between Gout and kidney disease, How Gout increase the risk of kidney Disease, and increase the level of uric acid. Hyperuricemia and gout, the clinical manifestation of monosodium urate crystal deposition are common in patients with chronic kidney disease CKD. While the presence of CKD poses additional challenges in gout management. effective urate lowering is possible for most patients with CKD, initial doses of urate lowering therapy are lower than in the non CKD population, while incremental dose escalation is guided by regulars monitoring of serum urate to reach the target. management of gout flares with presently available agents can be more challenging due to potential nephrotoxicity and or contraindication in the setting of other common comorbidities.

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