Relation between enteroviruses and acute flaccid paralysis
Acute flaccid myelitis (AFM) is a rare disease that affects the spinal cord, the part of the nervous system that carries messages to and from the brain. Before being described in 2014, AFM might have been diagnosed as a type of transverse myelitis. However, one difference between AFM and transverse myelitis has been found by magnetic resonance imaging (MRI) scans. The gray matter of the spinal cord is inflamed in people with AFM. AFP may be caused by several agents including Guillain-Barre Syndrome (GBS) (the most common cause), poliovirus, non-polio enterovirus( most common EV-D68 ), adenovirus, acute West Nile virus, campylobacter spp, transverse myelitis, peripheral neuropathy, acute non-bacterial meningitis, tick paralysis, and brain abscess. The onset of AFM is sudden (acute). Symptoms include weakness in one or more limbs (arms, legs), Flabby muscles affecting the face, head and neck, which might cause one side of the face to fall lower than the other, problems with swallowing or talking, problems with swallowing or talking, Weakness in muscles and nerves in the respiratory system, Pain in an arm or leg, and Inability to urinate. Guillain-Barre Syndrome is a reactive selflimited auto-immune disease in which the body's immune system attacks part of the peripheral nervous system and which presents as an acute generalized weakness. Enterovirus D68 is a single-stranded positive-sense RNA virus of the Picornaviridae family, belonging to the species enterovirus D. was first isolated from respiratory samples in 1962 in California, United States, was previously known as rhinovirus 87 until it was re-classified in 2002, and can cause mild to severe respiratory illness, or no symptoms at all. Mild symptoms may include runny nose, sneezing, cough, body aches, and muscle aches, and Severe symptoms may include wheezing and difficulty breathing. It likely spreads from person to person when an infected person coughs, sneezes, or touches a surface that is then touched by others.
Acute flaccid myelitis (AFM) is a rare disease that affects the spinal cord,and its by several agent like Guillain-Barre Syndrome , poliovirus, non-polio enterovirus( most common EV-D68 ).the onset of AFM is sudden.Symptoms include weakness in one or more limbs (arms, legs), Flabby muscles affecting the face.Enterovirus D68 is a single-stranded positive-sense RNA virus,was previously known as rhinovirus 87 until it was re-classified in 2002,It likely spreads from person to person.the aim of study is to know the is to know the relation of EV-D68 to the of acute flaccid paralysis.the study conducted a retrospective case–control study of children who had received medical care for any illness necessitating collection of nasopharyngeal specimens for respiratory pathogen testing in Colorado during August 3, 2014–October 18, 2014. the result show that EV-D68 is the most common cause.