sjogrens syndrome

El swadi, Noha Husein (2018-05-04)

Sjogren–Larsson syndrome nor Marines –Sjogren syndrome. is a long-term autoimmune disease in which the moisture-producing glands of the body are affected. This results primarily in the development of a dry mouth and dry eyes. Other symptoms can include dry skin, vaginal dryness,{1} a chronic cough, numbness in the arms and legs, feeling tired, muscle and joint pains, and thyroid problems. Those affected are at an increased risk (5%) of lymphoma. While the exact cause is unclear, it is believed to involve a combination of genetics and an environmental trigger such as exposure to a virus or bacteria. It can occur independently of other health problems (primary Sjogren syndrome) or as a result of another connective tissue disorder (secondary Sjogren syndrome). The inflammation that results progressively damages the glands. Diagnosis is by biopsy of moisture-producing glands and blood tests looking for specific antibodies.[ On biopsy there are typically lymphocytes within the glands. Between 0.2% and 1.2% of the population are affected,{1} with half having the primary form and half the secondary form. Females are affected about ten times as often as males and it commonly begins in middle age; however, anyone can be affected. Among those without other autoimmune disorders, life expectancy is unchanged


Sjogren's syndrome is an autoimmune disease. It is a chronic and slowly progressive disease. The main pathology being, lymphocytic infiltration of the exocrine glands, resulting in xerostomia and dry eyes. Though dryness of eyes, dryness of mouth and parotid enlargement are considered as triad of sjogren’s syndrome, rarely it can present as hypokalemic periodic paresis with renal tubular acidosis. Here, is a case report of patient having recurrent hypokalemic paresis, metabolic acidosis, type 1 renal tubular acidosis occurring secondary to sjogren’s syndrome

Attribution 3.0 United States
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