The Effect of CAR-T Cell Therapy in The Treatment of Cancer, And Associated Side Effects

Gnieber, Khalifa O. (2018-04-14)

When the immune system is functioning normally, immune cells move around the body looking for things that don’t belong, like bacteria and viruses. These immune cells search for invaders using “receptors”. When receptors find invaders in the body, special immune cells come in to destroy them; these cells are called cytotoxic T cells. Unfortunately, cancer cells are often able to hide from immune cells, which is why the cancer cells can grow out of control. Immunotherapy is a cancer treatment intended to make the body’s immune system able to detect and destroy cancer cells. Immune checkpoint inhibitors have been a successful immunotherapy approach because it pushes the immune system into high gear to fight cancer.


CAR-T Cell immunotherapy is an adoptive cell immunotherapy in which t-cells are reprogrammed to attack cancer cells through a specific surface antigen. It’s thought to be very effective, but side effects should also be considered. In this paper, three reports that study the effect of CAR-T Cell therapy on certain types of cancer, and associated side effects is discussed

Attribution 3.0 United States
Except where otherwise noted, this item's license is described as Attribution 3.0 United States