Neurological Manifestations in Systemic Lupus Erythematosus Patients
Systemic lupus erythematosus (SLE) is a multi-system, chronic inflammatory disease characterized by autoantibody production. The disease is most frequently found in women of childbearing age and therefore may co-exist with pregnancy. the clinical manifestations of the disease are variable , that varied from mild subtle signs like headache and mood disturbance to life threatening conditions like acute confusional state, stroke and myelopathy .the wide range of presentations and differential diagnosis often pose a very difficult diagnostic challenge for clinicians
Central nervous system (CNS) involvement has been emphasised as one of the major SLE manifestations since the first descriptions of the disease and is among the leading causes of morbidity and mortality. The aim of the present studies was to evaluate the various neurological manifestations in SLE and to assess the role of neuroimaging, electrophysiological studies in the diagnosis of subclinical neurological manifestations and to correlate neurological manifestations with disease activity.