How is Active Osteoarthritis Differ than Sero-negative Rheumatoid Arthritis in Clinical Diagnose ?

Eltarhuni, Nourfan G. (2018-06-30)

Clinical, epidemiologic and genetic data support the long-held contention that seropositive RA is a single disease entity. By contrast, comparable data suggest that the term “seronegative rheumatoid arthritis” has been used over the years to label patients who may not have rheumatoid disease. Many of these people have spondylarthritis or an arthropathy which cannot be classified


Arthritis comes in many forms. In fact, this term can apply to a number of conditions, including, rheumatoid arthritis, gout, and osteoarthritis. Two of these conditions–rheumatoid arthritis (RA) and osteoarthritis (OA) are often confused among patients.1 OA is a degenerative condition that develops because of excessive wear to the cartilage between the joints. RA is an autoimmune disease, chronic systemic inflammatory disease that affects about 1% of the population. It leads to irreversible joint damage and systemic complications, Since the discovery by Waalcr and Rose et al. of the so-called rheumatoid factor, patients have been classified as seropositive or seroncgative. Twenty years ago, textbooks stated that one quarter of rheumatoid patients were seronegative, only 38% of patients are diagnosed with seronegative RA

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