Clinical presentation and predisposing factor of recurrent aphthous stomatitis

salah, Abdulraof (2018-04-18)

Recurrent aphthous stomatitis (RAS) remains the most common ulcerative disease of the oral mucosa presenting as painful round shallow ulcers with well-defined erythematous margin and yellowish-gray pseudomembranous center. RAS has a characteristic prodromal burning sensation that lasts from 2 to 48 hours before an ulcer appears. It occurs in otherwise healthy individuals and is typically located on the buccal and labial mucosa and tongue. Involvement of the heavily keratinized mucosa of the palate and gingiva is less common. Several factors have been proposed as possible causative agents for RAS. These include local factors, such as trauma in individuals who are genetically susceptible to RAS, microbial factors, nutritional factors, such as deficiency of folate and B-complex vitamins, immunologic factors, psychosocial stress, and allergy to dietary constituents1 . Extensive research has focused predominantly on immunologic factors, but a definitive etiology of RAS has yet to be clearly established


Recurrent Aphthous Stomatitis (RAS) is the most common ulcerative disease affecting the oral mucosa. It occurs mostly in healthy individuals and has atypical clinical presentation in immunocompromised individuals. The etiology of RAS is still unknown, but several local, systemic, immunologic, genetic, allergic, nutritional, and microbial factors, as well as immunosuppressive drugs, have been proposed as causative agents. This review article summarizes the clinical presentation and predisposing factor of recurrent aphthous stomatitis.

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