Effect of depression on heart

Abstract

Depression and heart disease affect millions of people of all ages across all world regions; it is the second leading cause of death in 2030. Studies have shown that depression is a significant risk factor for heart disease and that it increases morbidity and mortality in patient suffer from previously heart disease Autonomic nervous system changes are often found in altered mood states and appear to be a central biological substrate linking depression to cardiovascular diseases. Alterations of autonomic nervous system functioning are reflected in reductions of heart rate variability (HRV) and other pathways such as endothelial dysfunction, platelet activity, inflammation and immune dysfunction that connect the depression to cardiac disease.