Paroxysmal Nocturnal Hemoglobinuria
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Date
2018-04-13
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faculty of Basic Medical Science - Libyan International Medical University
Abstract
Paroxysmal Nocturnal Hemoglobinuria originates from mutant genes in stem cells of bone
marrow that differentiate to different types of blood cells.Hemolytic anemia, bone marrow
failure and thrombophilia is Clinical triad typical for PNH. The management depend on patient
case
Description
Paroxysmal Nocturnal Hemoglobinuria is a very rare disease occurs in 1 every million
worldwide. It hard to differentiate its symptoms from other overlapping conditions, and takes
long time to be properly diagnosed.It is mainly caused by mutation in genes that code anchoring
proteins on different blood cells types. The different symptoms mainly depends on intravascular
hemolysis. The management aimed to correct the anemia and to prevent life-threatening
conditions as thrombi and intravascular clotting
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Except where otherwised noted, this item's license is described as Attribution 3.0 United States