Therapeutic Effects of Ketone Diet in Epilepsy
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Date
2018-06-30
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faculty of Basic Medical Science - Libyan International Medical University
Abstract
Ketogenic diet (KD) is a very low-carb diet, which forces the body to burn fat instead of
carbs making the body produce ketones as a fuel, this is an alternative fuel used in
conditions where glucose levels are low or for the treartment of seizures. KD has been
proven to be effective as a medical therapy for epilepsy allowing patients to take less or
no anti-epileptic drugs (AEDs), also providing a new line of therapy for those
unresponsive to AEDs. Despite its successful results, the exact mechanisms by which KD
works remains unclear. This is a collective review on the potential machanisms by which
KD exert its anti-seizures properties.
Description
Epilepsy is a common brain disorder characterized by recurrent seizures. Approximately
50 million people worldwide have epilepsy, making it one of the most common
neurological diseases globally1
. A wide range of antiepileptic drugs has been developed,
however about 30% of patients with epilepsy fail to respond. A high-fat, lowcarbohydrate
diet known as a ketogenic diet was developed to assist such patients, its
beneficial effects has been confirmed by a variety of clinical trials, one of them have
showed 75% decrease in seizures in children on a ketogenic diet for three months. Even
with these amazig results the excact mechanism through which a ketogenic diet excert its
anticonvulsant effects is unclear
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