Peptic ulcer and NSAIDs
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Date
2018-06-28
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faculty of Basic Medical Science - Libyan International Medical University
Abstract
Non-steroidal anti-inflammatory drugs including low-dose aspirin are some of the
most commonly used medicines. They are associated with gastrointestinal mucosal
injury.
Before prescribing, it is important to assess the patient’s gastrointestinal risk factors
such as age and history of peptic ulcers.
So this report will discuss the relation between peptic ulcer and NSAIDs
Description
Gastroduodenal ulceration and bleeding are the major limitations to the use of nonsteroidal anti-inflammatory drugs (NSAIDs). The development of safer NSAIDs or
of effective therapies for the prevention of the adverse effects of existing NSAIDs
requires a better understanding of the pathogenesis of NSAID-induced ulcer
disease. NSAIDs can cause damage to the gastroduodenal mucosa via several
mechanisms, including the topical irritant effect of these drugs on the epithelium,
impairment of the barrier properties of the mucosa, suppression of gastric
prostaglandin synthesis, reduction of gastric mucosal blood flow and interference
with the repair of superficial injury
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