The significance of gender differences on Diuretics pharmacodynamics

Abstract

Gender variations in pharmaceutical development have been demonstrated. In normal volunteers, researchers assessed the diuretic response of oral furosemide. each patient received single doses of the various diuretics Over the next 6 hours, total urine production was collected for volume measurement .There was no statistically significant difference in urine flow rate, between male and female individuals across treatments urine volume female after 6 hour was 367.2± 104.9 range from 216.0 to 518.4 ml and the mean of urine output among male after 6 hour was 468.0± 114.02 range from 302.4 to 604.8ml. urine output amount (P=0.142).