Gender-Related Differences in the Pharmacodynamics of Furosemide

Abstract

Many years ago theories has been established to request to involve females in all types of clinical drug development in order to investigate the potential gender differences of pharmacokinetics and pharmacodynamics of most of therapeutic agents specially the newly one. Since then, a lot of reports have been published that evaluate the potential existence and impact of gender differences on all phases of clinical pharmacology. In this research we focus on the pharmacodynamics of diuretics based on gender response. The results of these reports may will change the administration guidelines of these drug involve dose and mode of administration depends on the gender of patients.