The effect of gender differences on diuretic pharmacodynamics: (furosemide (Lasix)

Abstract

The average daily urine volume is 1L, The same load of solute can be excreted per 24 hours in a urine volume of 500ml. Normal urine output is 1-2 ml/kg/hr. Furosemide is a potent, short-acting diuretic (Loop Diuretics), and produces a natriuretic response in a 24-hour period. In these experiments, male and female groups experimental groups were used in these experiments, and they were given 40mg/kg of furosemide to quantify urine output after hours. Male subjects showed a greater peak sodium excretion rate than female subjects after treatment with oral and intravenous furosemide. There was no significant difference in urine flow rate, salt and potassium excretion rates between male and female individuals across treatments for natriuretic response.