Effect of Furosemide on adult males and females

Abstract

Throughout medical history, there have been very few instances of gender disparities in the correlation between dosage and effectiveness of a treatment. The purpose of this research was to investigate whether or not there was a difference in the pharmacodynamic properties of furosemide (FUR) between males and females. In both sexes, conventional renal clearance experiments were conducted in the absence and presence of a FUR dose required to produce similar FUR urine excretion ,in the absence of FUR , male and female fractional excretions of sodium, potassium, and water were identical . When stated in fractional terms , female had considerably higher natriuretic, kaliuretic, and diuretic responses to FUR , Female had higher diuretic, natriuretic,and kaliuretic efficiency than male. This could be explained by the reduced abundance of the Na-K-2Cl cotransporter found in homogenates from female kidney medullae compared to male kidney medullae.