Pharmacophores And Bioisosteres
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Faculty of Pharmacy
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The knowledge of a pharmacophore, or the 3D arrangement of features in the
biologically active molecule that is responsible for its pharmacological activity,
can help in the search and design of a new or better drug acting upon the same
or related target.
A bioisostere is a molecule resulting from the exchange of an atom or of a group
of atoms with an alternative, broadly similar, atom or group of atoms. The
objective of a bioisosteric replacement is to create a new molecule with similar
biological properties to the parent compound
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